Overview of Results
This page provides a summary of the PICOBOO study results, including plain language summaries, study design, methods, and final findings.
Plain Language Summaries
These summaries are designed to be easily understood by participants and the public. The version numbers and approval dates are provided for transparency.
Title: Early Results of a 2nd Booster in 50-69 Year Olds Primed with Astra Zeneca
File Name: PICOBOO Plain Language Summary AZ-AZ 50-69 2nd Booster
Version Number: V2.0
HREC Approval Date: 30/07/2024
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Title: Early Results of a 2nd Booster in 18-49 and 50-69 Year Olds Primed with Pfizer
File Name: PICOBOO Plain Language Summary PF-PF 18-69 2nd Booster
Version Number: V2.0
HREC Approval Date: 30/07/2024
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Study Design and Methods
These papers describe how the PICOBOO study was designed and the methods used, including important statistical considerations.
Title: Core Protocol for the Adaptive Platform Trial in COVID-19 Vaccine Priming and BOOsting
Date: 18 March 2023
Journal: Trials
Note: Published
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Title: Statistical Considerations for the Platform Trial in COVID-19 Vaccine Priming and Boosting
Date: 22 Jul 2024
Journal: Trials
Note: Published
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Title: The Platform trial In COVID-19 vaccine priming and BOOsting (PICOBOO) booster vaccination substudy protocol
Date: 01 Nov 2024
Journal: Trials
Note: Published
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Study Results
These papers present the final outcomes and findings of the PICOBOO study. Some publications are pre-prints, meaning they haven’t yet been reviewed by other experts.
Title: The immunogenicity, reactogenicity, and safety of different COVID-19 vaccinations administered as a second booster (fourth dose) in AZD1222 primed individuals aged 50-<70 years old
Date: 26 Sep 2024
Journal: Journal of Infection
Note: Published
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Title: The immunogenicity, reactogenicity, and safety of licensed COVID-19 vaccinations administered as a second booster in BNT162b2 primed individuals aged 18-<50 and 50-<70 years old
Date: 14 Nov 2024
Journal: Journal of Infection
Note: Published
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