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PICOBOO is a novel, innovative randomised clinical trial being conducted across multiple Australian sites that investigates the impacts of different COVID-19 vaccination strategies. This trial is designed to generate high-quality evidence to inform COVID-19 immunisation practice.

Whilst COVID-19 vaccines are approved for use in Australia to protect against COVID-19, there remains many unanswered questions about the best vaccination strategies. These include: How does vaccination impact on different aspects of the immune system? How long does immunity last? Does the optimal boosting strategy differ depending on age and previous receipt of COVID-19 vaccines?

The PICOBOO study, led by the Telethon Kids Institute, involves a collaborative team, including doctors, clinical researchers, laboratory specialists and policy makers. This trial is supported by the COVID-19 National Consumer Reference Group.

Ethics Approval

This project has been reviewed and approved by the Children and Adolescent Health SeThis project has been reviewed and approved by the Children and Adolescent Health Service Ethics Committee (RGS0000005222).