Thank you to everyone who helped find the best strategies for COVID-19 vaccine boosting in Australia by participating in the PICOBOO study.

We researched the best strategies for COVID-19 booster vaccination to protect Australians from infection and severe disease. Explore our findings.

646 Australians helped researchers investigate the best strategies for COVID-19 booster vaccination. See what we found.

PICOBOO is a novel, adaptive clinical trial investigating the effectiveness and safety of different COVID-19 booster vaccines. Since March 2022, we have completed 1,110 vaccine doses, over 5,000 study visits, and processed more than 100,000 biological samples.

While booster vaccines are available in Australia to protect against COVID-19, important questions remain about which vaccines work best, for whom, and how long protection lasts. PICOBOO is helping to answer these questions to guide future vaccination recommendations.

Enrolment is now permanently closed. We are deeply grateful to all 646 participants and their families across our study sites in Perth, Adelaide, and Launceston for their invaluable contribution to this research.

We are now focused on analysing results and publishing our findings to inform COVID-19 vaccination policy across Australia. Participants continue to receive short follow-up surveys every 3 months, with the final surveys expected to be completed by late 2026.

For further information about the study, please click here.